Featured Game: Indianapolis Colts (-4.5 -105, 43.5) vs. Tennessee Titans
Time: 1:00 pm ET / 4:00 pm PT
Television: CBS, Paramount, NFL+
NFL Week 3 Betting Preview: Colts vs. Titans – Indianapolis Looks to Stay Undefeated
The Indianapolis Colts (2-0) aim to stay perfect on the road as they face the struggling Tennessee Titans (0-2) in a pivotal AFC South matchup. Head coach Shane Steichen will lean heavily on the run game, targeting a Titans defense that ranks 27th in rushing yards allowed, giving up an average of 150 yards per game through two weeks.
That’s a major concern for Brian Callahan’s Titans, especially against a Colts offense that’s averaging 161.5 rushing yards per game—third-best in the NFL during their two victories.
Injury issues continue to mount for Tennessee. Nose tackle T’Vondre Sweat, their top run-stopper, has been ruled out for Sunday. Cornerback L’Jarius Sneed is listed as questionable, and while insiders expect him to suit up, he hasn’t proven he can handle a full workload.
Offensively, the Titans will be without starting right tackle JC Latham, and three other starters—including right guard Kevin Zeitler, who hasn’t practiced all week—are questionable. That’s bad news for a unit that’s already allowed a league-high 11 sacks.
The betting market has responded: the line has shifted six points, with over 70% of the money backing the Colts. Indianapolis has covered five of their last six division games and has won four straight against the Titans ATS.
This matchup sets up perfectly for bettors looking to ride the Colts’ momentum and exploit Tennessee’s injury-riddled roster. Want help building a same-game parlay or finding value on the total? Let’s break it down.
Pick: Indianapolis Colts -4.5 -105
