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Game:

USC Trojans at Notre Dame Fighting Irish

Date:

Saturday, Oct 18, 2025

Time:

07:30 pm EDT

Television:

NBC

Odds:

USC Trojans +10 (-110)

Notre Dame Fighting Irish -10 (-110)

The Trojans have been elite between the 20s, but their red zone touchdown rate in road games drops to about 55 percent compared to more than 70% at home. USC also just converts 55% of third downs overall but only 44% on the road. USC is 2-10 ATS on the road since 2023, tied for worst in FBS during that stretch. Notre Dame is 16-5 ATS against ranked opponents since 2022, best in FBS (min. 10 games). The Fighting Irish are 22-9 ATS as a favorite since 2023, best among power conference teams (min. 15 games).

Play: (416) Notre Dame Fighting Irish -10 (-110)

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